Centriole Assembly: The Origin of Nine-ness
نویسندگان
چکیده
منابع مشابه
Centriole Assembly: The Origin of Nine-ness
Recent studies of the Chlamydomonas bld10 mutant have revealed that the ninefold symmetry of the centriole is set by the length of the cartwheel spokes, which fixes the diameter, and thereby the circumference, of the centriole.
متن کاملStepwise evolution of the centriole-assembly pathway.
The centriole and basal body (CBB) structure nucleates cilia and flagella, and is an essential component of the centrosome, underlying eukaryotic microtubule-based motility, cell division and polarity. In recent years, components of the CBB-assembly machinery have been identified, but little is known about their regulation and evolution. Given the diversity of cellular contexts encountered in e...
متن کاملThe de novo centriole assembly pathway in HeLa cells: cell cycle progression and centriole assembly/maturation
t has been reported that nontransformed mammalian cells become arrested during G 1 in the absence of centrioles (Hinchcliffe, E., F. Miller, M. Cham, A. Khodjakov, and G. Sluder. 2001. Science . 291:1547–1550). Here, we show that removal of resident centrioles (by laser ablation or needle microsurgery) does not impede cell cycle progression in HeLa cells. HeLa cells born without centrosomes, la...
متن کاملKinetics and regulation of de novo centriole assembly Implications for the mechanism of centriole duplication
BACKGROUND Centriole duplication is a key step in the cell cycle whose mechanism is completely unknown. Why new centrioles always form next to preexisting ones is a fundamental question. The simplest model is that preexisting centrioles nucleate the assembly of new centrioles, and that although centrioles can in some cases form de novo without this nucleation, the de novo assembly mechanism sho...
متن کاملCep120 is asymmetrically localized to the daughter centriole and is essential for centriole assembly
Centrioles form the core of the centrosome in animal cells and function as basal bodies that nucleate and anchor cilia at the plasma membrane. In this paper, we report that Cep120 (Ccdc100), a protein previously shown to be involved in maintaining the neural progenitor pool in mouse brain, is associated with centriole structure and function. Cep120 is up-regulated sevenfold during differentiati...
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ژورنال
عنوان ژورنال: Current Biology
سال: 2007
ISSN: 0960-9822
DOI: 10.1016/j.cub.2007.10.038